It is possible, A&N has a few changes most notable of which is the addition of a set of game tips to the game tip library. It is very, very time consuming though, just finding the UI Data(s) that you need to change can take an awful long time. A full redesign a bit too ambitious though, Maxis must have a graphical tool for creating the UI as indicated by the "# Generated by UI editor" found at the top of each.
As an aside the UI Data files in basegame group 0x499DB772 that
SimPE seems unable to read are actually movie files.